I know it is kinda frowned on but I like to use new directories at root to cut down on confusion as to where things are. Video storage for the NVR goes in /video, user data for Nextcloud goes in /data, etc. But I also keep everything in it’s own LXC so I don’t have one machine with 30 extra directories cluttering up the root.
Around 2007 I had a Windows laptop die on me and drove me to device agnosticism. Maybe I learned the wrong lesson but now I keep my OS and data separate enough that a b0rked OS is an hour’s inconvenience instead of a day’s recovery.
Still, it’s pretty awesome that you can just shuck a drive into a totally new machine and only have to adjust network settings.