Holy fuck, that last level! Dude, you have unlocked some deep seated trauma.
Holy fuck, that last level! Dude, you have unlocked some deep seated trauma.
Dude, you meant Dutch, not Danish?
I like it…
Lucky for them, eh?
Does the Pope shit in the woods!?!
Eat long veg, grow long dong.
Holland is also flat as fuck
Fanny milk, not available in the UK.
Go on
-Merchants will be required to put signs in front of all products that have been reduced in size without a corresponding price cut.
What’s to stop the manufacturer reducing the item by, for example, 10% in size, and 2% in price?
Lemmy see how this all plays out
It’s not about money, it’s about having a teeny tiny bit of authority over others in your otherwise meaningless existence.
Abstract
High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) signalling in macrophages has been implicated in the pathogenesis of ischaemic cardiovascular disease. In a series of clinical studies on male and female participants (NCT03946774 and NCT03994367) that involved graded amounts of protein ingestion together with detailed plasma amino acid analysis and human monocyte/macrophage experiments, we identify leucine as the key activator of mTOR signalling in macrophages. We describe a threshold effect of high protein intake and circulating leucine on monocytes/macrophages wherein only protein in excess of ∼25 g per meal induces mTOR activation and functional effects. By designing specific diets modified in protein and leucine content representative of the intake in the general population, we confirm this threshold effect in mouse models and find ingestion of protein in excess of ∼22% of dietary energy requirements drives atherosclerosis in male mice. These data demonstrate a mechanistic basis for the adverse impact of excessive dietary protein on cardiovascular risk.
Or OneDrive.
File > Save As > Desktop.
Doesn’t save to local Desktop, but the OneDrive desktop wherever the fuck that is.
Drinks are served in jars, and your fries, well, you get 8 fries in a rusty old can.
This ain’t your first rodeo, eh?
Oh, bye then.